Will it run on a GTX 960 and AMD FX-8350?

Ram - 16.0GB Dual-Channel DDR3 @ 669MHz (9-9-9-24)
Motherboard - Gigabyte Technology Co. Ltd. 990FXA-UD3 (CPU 1)

Can I hit high fps on all lowest settings?

Well it's still in beta stage and given you could take two separate machines with the same hardware but different users own them, it could result in two completely different performances. What I'm getting at though, is it may run fine for you but it could be stuttering a lot for another. The official system requirements are not out yet, so if you're thinking about purchasing and are concerned, just wait for the official specs to be released.